Exonic enhancers: proceed with caution in exome and genome sequencing studies
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Wikipedia: proceed with caution.
Despite the study's strengths, a minor obstacle in the methodology should be noted. Hasty et al 9 point out that a reporting bias by the reviewers may have caused a discrepancy in dissimilar assertions that failed to show discordance. What 1 reviewer counted as an assertion, another might not have, and thus this was purely left to the subjec-tivity of the reviewer. Different results might have ...
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Introduction Next-generation DNA sequencing empowers scientists to identify genetic variations associated with human disease at higher resolution and greater sensitivity than previously possible. Two approaches are commonly employed -exome sequencing and whole genome sequencing. Exome sequencing targets protein-coding regions comprising approximately 1% of the human genome, while whole genome s...
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The federal tax code creates challenges for comparing the profit rates of different banks on a consistent basis. The earnings of banks that elect to operate under subchapter S of the federal tax code are not subject to federal corporate income tax, but shareholders of these “S-banks” are taxed on their pro rata share of the entire earnings of the bank. The number of banks electing subchapter S ...
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The emergence of urgent care centres in the United States signifies an innovative response to the demands-public, private and governmental-to control the rising costs of health care. What is immediately obvious to the practitioner, however, may or may not be quite so obvious to the consumer. Simply expressed, trade-offs must be made. In the accompanying article 'Urgent Care Centres', Drs Janiak...
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Five different measures of gametic disequilibrium in current use and a new one based on R. C. Lewontin's D', are examined and compared. All of them, except the measure based on Lewontin's D', are highly dependent upon allelic frequencies, including four measures that are normalized in some manner. In addition, the measures suggested by A. H. D. Brown, M. F. Feldman and E. Nevo, and T. Ohta can ...
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ژورنال
عنوان ژورنال: Genome Medicine
سال: 2016
ISSN: 1756-994X
DOI: 10.1186/s13073-016-0277-0